metabolic disease — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9491	Pyraclostrobin		Antibacterial , Antifungal
	Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.		Antibacterial , Antifungal
T9609	GRK5-IN-2		GRK
	GRK5-IN-2, a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor. It regulates the expression and/or release of insulin and is useful for the metabolic disease research.		GRK
T2216	Entacapone	OR-611	Transferase
	Entacapone (OR-611) is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT).		Transferase
T4733	Sucrose	D(+)-Sucrose,D-(+)-Saccharose	Others , Endogenous Metabolite
	Sucrose (D-(+)-Saccharose) is a nonreducing disaccharide composed of glucose and fructose linked via their anomeric carbons.		Others , Endogenous Metabolite
T12931	SLC13A5-IN-1		Stearoyl-CoA Desaturase (SCD)
	SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5),completely blocks the uptake of 14C-citrate(IC50 : 0.022 μM in HepG2 cells).		Stearoyl-CoA Desaturase (SCD)
T31611	Eldacimibe	WAY-ACA-147,UNII-4PBL76O2G8,ANA 147,ACA 147	Acyltransferase
	Eldacimibe (WAY-ACA-147) is an ACAT2 inhibitor for the treatment of cardiovascular disease and endocrine and metabolic disorders, study of atherosclerosis and hypercholesterolemia.		Acyltransferase
T6112	Doxercalciferol	TSA 840,Hectorol,1.alpha.-Hydroxyvitamin D2,1α-hydroxyvitamin D2	Others
	Doxercalciferol (TSA 840) is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease.		Others
T13230	TXNIP-IN-1		Others
	TXNIP-IN-1 is an inhibitor of the TXNIP-TRX complex and used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease.		Others
T60150	(1S,2R)-Alicapistat		Cysteine Protease
	(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is a highly efficient, orally active compound that selectively inhibits human calpains 1 and 2, with promising implications for Alzheimer's disease (AD) therapy [1]. This compound ef...		Cysteine Protease
T31992	Granotapide		CETP
	Granotapide is a microsomal triglyceride transfer protein (MTP) inhibitor that treats and rather prevents atherosclerosis, coronary artery disease, metabolic syndrome, obesity, diabetes mellitus, prediabetes mellitus, an...		CETP
T5623	Bisphenol A		Others , Endogenous Metabolite
	Bisphenol A is an endogenous metabolic compound of phenols and is widely used in the production of epoxy resins and polycarbonate plastics. It is reproductive, developmental and systemic toxicant and is often classified ...		Others , Endogenous Metabolite
T27245L	Eflucimibe	L0081,F-12511	Acyltransferase
	Eflucimibe (L0081) is an acyl coenzyme A: cholesterol acyltransferase inhibitor for the treatment of cardiovascular disease and endocrine and metabolic disorders, and can be used to study atherosclerosis and hyperlipidem...		Acyltransferase
T5253	3-Methyladipic acid		Others , Endogenous Metabolite
	3-Methyladipic acid is a metabolite of the catabolism of phytanic acid. Patients with adult Refsums disease (ARD) are unable to detoxify phytanic acid by alpha-oxidation, and so the w-oxidation pathway is the only metabo...		Others , Endogenous Metabolite
T111959	IFB-088 acetate
	IFB-088 acetate, a benzyl guanidine derivative, is used to treat diseases and cancers associated with the PPP1R15A pathway and associated with protein misfolding stress, Examples include tau disease, synaptic riboprotein...
T0256	Citric acid trilithium salt tetrahydrate	Lithium citrate tribasic tetrahydrate,Trilithium citrate tetrahydrate	Dehydrogenase , GSK-3 , HIF/HIF Prolyl-Hydroxylase , Antibacterial , GluR
	Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways...
T8274	3-Methyl-L-histidine		Endogenous Metabolite
	3-Methylhistidine belongs to the class of organic compounds known as histidine and derivatives. Histidine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at t...		Endogenous Metabolite
T61743	PPARγ agonist 2
	PPARγ agonist 2 is a highly effective compound that acts as a partial agonist for PPARγ. It exhibits significant potential for utilization in metabolic disease research [1].
T35886	L-hydroxy Arginine (acetate)
	L-hydroxy Arginine is a substrate for nitric oxide synthase in the catabolism of L-arginine to form nitric oxide. It has been used as a biomarker for reduced nitric oxide formation in patients with cardiovascular disease...
T63818	Omesdafexor
	Omesdafexor is an FXR agonist that can be used to study diseases caused by liver disease or metabolic inflammation.
T83533	(R)-Monlunabant	(R)-MRI-1891	Cannabinoid Receptor
	(R)-Monlunabant ((R)-MRI-1891) serves as a CB1 receptor antagonist utilized in obesity and metabolic disease research [1].		Cannabinoid Receptor